Publications

Mass Drug Administration (MDA) programs for scabies involving MCRI

  • "Mass drug administration for scabies control in a population with endemic disease"
    Mass Drug Administration (MDA) program in Fiji involving 2051 participants across three island communities, each community receiving a different treatment arm. Primary outcome was the change in the prevalence of scabies and impetigo from baseline to 12 months. Results concluded that MDA, particularly ivermectin, was efficacious.
    Romani L, Whitfeld MJ, Koroivueta J, Kama M, Wand H, Tikoduadua L, et al. Mass drug administration for scabies control in a population with endemic disease. N Engl J Med. 2015;373:2305–13  https://www.nejm.org/doi/full/10.1056/nejmoa1500987

  • "Mass Drug Administration for Scabies – 2 Years of Follow-up"
    24 month follow up survey of the above MDA program conducted to determine the durability of a single round of MDA, which found that ivermectin-based MDA was efficacious in reducing prevalence of scabies from baseline to 24 months. Researchers called for evaluation of MDA in larger, less isolated populations to extend their findings.
    Mass Drug Administration for Scabies - 2 Years of Follow-up.  Romani L, Whitfeld MJ, Koroivueta J, Kama M, Wand H, Tikoduadua L, Tuicakau M, Koroi A, Andrews RM, Kaldor JM, Steer AC.  N Engl J Med. 2019 Jul 11;381(2):186-187. doi: 10.1056/NEJMc1808439. PMID: 31242358 https://www.nejm.org/doi/10.1056/NEJMc1808439

  • "Efficacy of mass drug administration with ivermectin for control of scabies and impetigo, with coadministration of azithromycin: a single-arm community intervention trial."
    MDA involving azithromycin (for trachoma) and ivermectin, offered to an entire island population in Solomon Islands (>26,000), with two sets of ten sentinel villages selected for monitoring over 12 months. Results concluded that ivermectin-based MDA can be scaled to a population of over 25,000 with high efficacy.
    Romani L, Marks M, Sokana O, Nasi T, Kamoriki B, Cordell B, Wand H, Whitfeld MJ, Engelman D, Solomon AW, Kaldor JM, Steer AC.  Lancet Infect Dis. 2019 May;19(5):510-518. doi: 10.1016/S1473-3099(18)30790-4. PMID: 30956111. https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(18)30790-4/fulltext

  • "Prevalence of scabies and impetigo three years after mass drug administration with ivermectin and azithromycin."
    36 month follow up survey of the above MDA program in Solomon Islands, concluded that a single round of ivermectin/azithromycin MDA had a sustained impact on scabies and impetigo prevalence 3 years post intervention.
    Marks M, Romani L, Sokana O, Neko L, Harrington R, Nasi T, Wand H, Whitfeld MJ, Engelman D, Solomon AW, Kaldor JM, Steer AC.  Clin Infect Dis. 2019 May 25. pii: ciz444. doi: 10.1093/cid/ciz444. PMID: 31131410. https://europepmc.org/article/med/31131410

  • "Feasibility and safety of mass drug co-administration with azithromycin and ivermectin for the control of neglected tropical disease: a single-arm intervention trial"
    Evaluation of safety and feasibility of the above MDA trial, finding that the combination of ivermectin/azithromycin in MDA on a population of over 25,000 was safe and feasible.
    Romani L, Marks M, Sokana O, Nasi T, Kamoriki B, Wand H, et al. Feasibility and safety of mass drug co-administration with azithromycin and ivermectin for the control of neglected tropical diseases: a single-arm intervention trial. Lancet Glob Health. 2018;6:e1132–8. https://pubmed.ncbi.nlm.nih.gov/30223985/

  • "The safety of combined triple drug therapy with ivermectin, diethylcarbamazine and albendazole in the neglected tropical disease co-endemic setting of Fiji: A cluster-randomised trial."
    MDA comparison in Fiji involving treatment with combination of diethylcarbamazine and albendazole (established treatment for lymphatic filariasis) and combination of ivermectin, diethylcarbamazine, and albendazole. Entire island community offered treatment and randomised to either group. The addition of ivermectin to the established 2-drug treatment was found to be safe.
    The safety of combined triple drug therapy with ivermectin, diethylcarbamazine and albendazole in the neglected tropical diseases co-endemic setting of Fiji: A cluster randomised trial, Myra Hardy, Josaia Samuela, ….. John M. Kaldor, Andrew C. Steer. https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008106

 

Introduction to the International Alliance for the Control of Scabies (IACS)

  • "Toward the global control of human scabies: introducing the International Alliance for the Control of Scabies"
    Engelman D, Kiang K, Chosidow O, McCarthy J, Fuller C, Lammie P, et al. Toward the global control of human scabies: introducing the International Alliance for the Control of Scabies. PLoS Negl Trop Dis. 2013;7:e2167. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738445/

  • "The public health control of scabies: priorities for research and action"
    Engelman D, Cantey PT, Marks M, Solomon AW, Chang AY, Chosidow O, et al. The public health control of scabies: priorities for research and action. Lancet. 2019;394:81–92. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)31136-5/fulltext

  • "Consensus criteria for the diagnosis of scabies: A Delphi study of international experts"
    Engelman D, Fuller LC, Steer AC, Panel for the International Alliance for the Control of Scabies Delphi panel. Consensus criteria for the diagnosis of scabies: a Delphi study of international experts. PLoS Negl Trop Dis. 2018;12:e0006549. https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006549

 

Mass Drug Administration studies outside of MCRI

  • "Control of scabies, skin sores and haematuria in children in the Solomon Islands: Another role for ivermectin" - Solomon Islands
    MDA program with ivermectin treatment almost all residents of 5 small islands in the Solomon Islands. Results showed that ivermectin was effective and practical in controlling scabies, as well as reducing the occurrence of streptococcal skin disease. Researchers called for the integration of scabies control programs with filariasis/intestinal nematodes control methods.  
    Lawrence G, Leafasia J, Sheridan J, Hills S, Wate J, Wate C, et al. Control of scabies, skin sores and haematuria in children in the Solomon Islands: another role for ivermectin. Bull World Health Organ. 2005;83:34–42. https://pubmed.ncbi.nlm.nih.gov/1673175/

 

Disease Burden Studies

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